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While marked phenotypes have not been reported for these systems, they have been used to try to establish the importance of the enzymes

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Next, the protein expression levels of ferroptosis-related factors were assessed through western blotting

The X-box-binding protein-1 (XBP1), spliced and activated by IRE1, is downregulated in glomerular mesangial cells, weakening the inhibitory effect on the phosphatase and tensin homolog (PTEN)/Akt pathway, thereby aggravating kidney damage

A thorough evaluation by an endocrinologist is required before enrollment