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They were then applied in vitro and in vivo, demonstrating the great potential of this protein but also of the delivery system that is able to increase permeability across the eye barriers and allow prolonged release over time (Singh et al

However, its endocrine effects may influence the action or monitoring of certain medications

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23 This need for injection can limit patient use and may also restrict the possibility of combining these drugs in fixed-dose treatments with other therapies for cardio-metabolic conditions