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Histamine acts as a neurotransmitter involved in the contractions of the intestinal muscles.[ref] People with food allergies and IBS had significantly higher levels of H1 and H2 receptors in their intestines.[ref] Histamine receptors in the brain: A 2026 study explored the role of histamine and histamine receptors in different regions of the brain

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The encouraging part is that this kind of environment-driven pigmentation is very treatable

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However, if the accumulation of acetaldehyde occurs faster than the action of aldehyde dehydrogenase (such as during a heavy drinking session), this can result in a bad hangover