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When HOXA2 is overexpressed, SIRT1 transcription is increased, which in turn promotes the deacetylation and inactivation of ATF6, eventually alleviating renal fibrosis by inhibiting ER stress in CKD

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However, when compared with baseline, SBP did not appreciably change after treatment with ALC whereas it significantly decreased in patients allocated to placebo (from 138.1 18.3 mm Hg to 134.5 15.1 mm Hg

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