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It has been shown that about 20 PD susceptibility genes (PRKN, SNCA , etc.) are involved in the process of mitochondrial autophagy and regulation of mitochondrial function, and patients with inherited PD caused by mutations in these genes present with impairment of the mitochondrial autophagic pathway and mitochondrial dysfunction

Although there is no close relationship between plasma VPA concentrations and the severity of CNS toxicity [11, 86], patients who ingest more than 200 mg/kg VPA and/or have plasma concentrations greater than 180 g/ml usually develop severe CNS depression