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"Fully human antibodies, as used herein, are antibodies comprising "human" variable region domains and/or.CDRs, as defined above, without substantial non-human antibody sequences or without any non-human antibody sequences

hydropathic amino acid index in conferring interactive biological function on a protein is generally understood in the art Kyte and Doolittle, 1982, incorporated herein by reference)

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the human immune system should not recognize the antibody as foreign