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Berberine and zinc Berberine, a well-known natural isoquinoline alkaloid, is found in a variety of plants, such as Coptis and Berberis (Cicero and Baggioni 2016)

(2022) observed that although a two-month synbiotic intervention consisting of 510 9 CFU Lactobacillus acidophilus and Bifidobacterium longum and 60 mg of FOS in a double-blinded randomized controlled clinical trial involving hemodialysis patients with gastrointestinal complaints had a substantial effect in improving constipation and general quality of life in the synbiotic group, it did not reduce the levels of IS in their serum compared to the placebo group

Kiaris H, et al

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411,412,413 The promotion of SCFA-producing bacteria induced by dietary fibers observed in T2DM patients suggests the potential value of fiber supplementation in clinical practice