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Description

Variants in FTO , GLP1R , MC4R , and TCF7L2 map the baseline metabolic terrain any GLP-1 compound operates on, describing appetite regulation and energy balance rather than predicting response to a specific drug

Phase II trial data published in the New England Journal of Medicine (2023) demonstrated meaningful weight reduction in adults with obesity

They can also increase the risk for malnutrition. Hydration

Avoid intense exercise if it exacerbates discomfort

Treatment was associated with improvements in executive function, assessed with the Trail Making TestPart B (TMT-B), along with metabolic benefits [78]