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No, the proportion of lean mass lost with GLP-1 medications (approximately 2040% of total weight loss) is similar to other weight loss interventions including dietary restriction and bariatric surgery

Human Reproductive Biology (Academic Press, 2013)

Also, adding a very low-calorie diet to the treatment with semaglutide produced more weight loss than semaglutide alone

(2016) is that they utilized not only novel sandwich enzyme-linked immunosorbent assays of plasma glucagon but also mass spectrometry-based proteomics to confirm 29-amino acid circulatory glucagon levels in patients without a pancreas