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Fourth, there was a substantial level of heterogeneity among the studies in more analyses

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The mechanism of action of semaglutide in patients with obesity is similar to that of liraglutide primarily energy intake reduction but semaglutide has also been shown to improve control of eating and food cravings and reduce preference for fatty, energy-dense foods (6), suggesting that semaglutide may affect food intake via hedonic as well as homeostatic pathways

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