Historically described as mere fat-solubilizing agents, these amphipathic compounds were recently recognized as key signaling molecules capable to modulate the host metabolism directly acting as ligands of intestinal GPCRs (101, 338, 339), or after being metabolized by the colonic microbiota into secondary bile acids, mostly deoxycholic and lithocholic acid(340)
Dudek KA, Dion-Albert L, Lebel M, LeClair K, Labrecque S, Tuck E, et al
Stomach side effects (nausea) most likely to show up here
Peptide therapy reproduces these functions to optimize health
Pharmacologically blocking CXCR4 or genetically depleting CXCL12 in LECs enhances CD8+ T cell retention and promotes anti-cancer immunity (97)