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The Zepbound prescribing information specifies starting at 2.5mg with four-week titration intervals

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Circ Res (2022) 130(5):694707

In conclusion, this work shows that GLP-1 exerts its lipolysis effects on pancreatic -cells by inducing the expression and production of secreted FNDC5 derivatives

But as our clinical practice continues to reveal, many people experience a troubling shift toward constipation or slowed motility after starting these medications