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10.1152/ajplung.00110.2004

The reduction in fatty acid levels appears to be the molecular signal leading to increased expression of NPY and AgRP

However, patients should not self-treat severe or persistent constipation without medical advice, especially if they develop pain, bloating, vomiting, inability to pass stool or gas, or rectal bleeding

One such option would be utilizing antioxidant therapies to neutralize reaction oxygen species (ROS) in the retina that underlie RP progression