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The Muscle Preservation Challenge Significant weight loss inevitably involves some degree of lean mass reduction

For a fuller explanation of these protein guidelines, including why protein needs are higher when dieting, see our article: How to Set Your Macros for Fat Loss and Muscle Growth

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"Skin elasticity also plays a role, particularly with quicker or larger-volume loss, leading to a looser appearance for some people." Are these changes specific to Ozempic