Species differences in metabolism, receptor expression, and pharmacokinetics mean that effective doses in rats do not predict safe or effective doses in humans
This demonstrates that cells are actively resisting oxidative damage and initiating repair mechanisms, thereby corroborating the presence and intensity of OS from another perspective
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Weihong Zhang, [email protected] These authors have contributed equally to this work and share first authorship Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers
Figure 3: Homocysteine (Hcy) follows two pathways in cells: one turns it into methionine, and the other into cystathionine