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For instance, a double-blind, placebo-controlled study in 80 healthy men, aged 18 to 42 years, found that use of a multivitamin/mineral supplement for 28 days was associated with reductions in the subjective measures of anxiety and perceived stress (138)

We propose that the seemingly opposing roles of GSH in cell survival and cell death reflect the spatial, metabolic, and microenvironmental context in which GSH homeostasis is disrupted

Mechanistic studies should further delineate the relative contributions and potential synergies between its primary pathwaysparticularly SIRT1/AMPK, PI3K/Akt, and PPAR signalingand evaluate its impact on specific patient subgroups stratified by biomarkers like AMH or gut microbial signatures

doi: 10.1016/j.arcmed.2016.07.003 225 Samsami-korMDaryaniNEAslPRHekmatdoostA

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