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Available at [Accessed on 17 March, 2025] Hattori, Y., Nakaoku, Y., Ogata, S., Saito, S., Nishimura, K., & Ihara, M

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Tie-2 is the tyrosine kinase receptor for Ang-1 and Ang-2, molecules that regulate angiogenesis and endothelial cell survival, proliferation and migration (73)

Cohort details, including sample size of each cohort, allele frequency in the population are provided in supplemental information (Additional file 1: Supplementary methods Sect