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Methods In order to gain insights into the molecular pathways underlying progression of emphysema and explore computational strategies for identifying COPD therapeutics, we profiled gene expression in lung tissue samples obtained from regions within the same lung with varying amounts of emphysematous destruction from smokers with COPD (8 regions 8 lungs = 64 samples)

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Vertical bands involving underlying muscle (platysmal bands) respond less to topical treatment but may still show some improvement in overlying skin texture

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