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Indications: Treatment resistant hypertension Most often used as a supplemental drug that is added on to a daily treatment regimen for patients with hypertension that is not adequately controlled by a combination of lifestyle modification, thiazide diuretic, plus an ACE inhibitor or Angiotensin receptor blocker (Brook & Townsend, 2026)

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For hypothalamic amenorrhea, prioritize slow caloric and weight restoration, stop over-exercising, and steer clear of insulin-sensitizing peptides that can exacerbate underweight conditions