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Since the mevalonate pathway is closely related to ferroptosis through regulating expression of GPX4, production of squalene and coenzyme Q, and sterols are known to exert intricate feed-back regulations on this pathway to restrict cholesterol overproduction, we hypothesized that cholesterol and its metabolites would modulate cell sensitivity to ferroptosis

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Although this compensatory response may have confounded measurement of the true contribution of HSL to adipose fatty acid mobilization, it is clear from a number of studies that HSL is not strictly required for the initiation of TAG hydrolysis

Oleuropein as a novel anti-diabetic nutraceutical