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There's no way to guarantee in advance which one you'll tolerate better, which is why we start low, go slow, and adjust as needed

[26] The same critics claimed that previous controlled trials "found no evidence that chelation is superior to placebo for treatment of CAD [Coronary Artery Disease] or PVD [Peripheral Vascular Disease]," making the trial "unethical, dangerous, pointless, and wasteful." [3] Evidence of insurance fraud and other felony convictions among (chelation proponent) investigators further undermined the credibility of the trial

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Progestins are meant to function like natural progesterone, but a huge body of data indicates potential for adverse side effects