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Researchers in 2026 should evaluate both compounds against current Phase 3 data as it becomes available

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Intracellular L-serine levels initially remain stable but significantly increase after 24 h of serine depletion, while intracellular and extracellular glycine levels decrease but recover after 24 h

Therefore, while GLP-1RAs may represent a promising therapeutic option for managing psoriasis, further high-quality studies are needed to distinguish whether the therapeutic effects of GLP-1RAs originate from the direct regulation of immune cells or improvements in comorbidities such as obesity or diabetes