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A pattern of 12 weeks on, 4-6 weeks break, repeated several times, produces sustainable results without the receptor desensitization that can occur with extremely long continuous use

In cultured fibroblasts, exposure to the compound at concentrations as low as 10 nM has produced measurable increases in collagen synthesis within 48 hours

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Who should check with a provider first If you are pregnant, nursing, have kidney disease, or take medications that interact with B12 metabolism (such as metformin), discuss this with a provider before starting

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