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A French nationwide case-time-control study of completed suicides and suicide attempts found no specific risk related to prior psychiatric history or obesity during GLP-1 RA use ( 5 State of the art and future directions No clear causal mechanism linking GLP-1 RA use to suicidality has been established

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Some GLP-1 medications, including semaglutide, have been linked to cases of pancreatitis

Some patients find evening injections convenient because they can minimize appetite-suppression side effects during sleep