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Epithelial-mesenchymal transition in cancer: A historical overview

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77 Tobacco smoking increases stop-gain mutations, which may lead to early termination of protein-coding and disrupt the formation of tumor suppressor factors, thereby elevating the susceptibility to breast cancer

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In general, PT-141 should not be administered more than twice weekly or eight times monthly, since overly frequent administration can increase the risk of side effects such as skin darkening