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By integrating various genomic data types, including gene expression profiles, genetic variants, and epigenetic modifications, functional genomics is accelerating the discovery of genes that are not only associated with OA but also play a functional role in its pathogenesis

Upon adenosine diphosphate (ADP) activation, the P2RY12 receptor interacts with Gi and inhibits adenylate cyclase activity (168)

By analyzing the aortic tissue, we found that FOXO4-DRI treatment significantly increased the expression levels of Ki-67 and Lamin B, while reducing the expression of P21, P16, and -H2AX, similar to the results obtained from naturally aged mice (Figure 2A)

The tight connection between telomeres and mitochondrial function is evident in the activation of p53 when telomere function is impaired, leading to the suppression of PGC1 and PGC1 expression

By day 14, some mice showed a decrease in gap detection ratios, with no significant difference from the controls ( F 1,6 = 0.096, P = 0.767)