By increasing the overall degradation capacity, these agents facilitate more efficient clearance of ubiquitinated proteins and reduce the proteotoxic burden
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suggests that multiple amino acid substitutions are introduced to support the peptides stability against enzymatic degradation potentially: (1) Position 2 (Alanine D-Alanine): Introduces a D-form amino acid, which is less susceptible to standard enzymatic breakdown
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The practical non-invasive nature of nasal dosing also improves user comfort and protocol adherence in repeated-dose study designs