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The FDA based its efficacy evaluation of gepirone ER on 13 trials: 12 acute treatment trials and 1 maintenance or relapse prevention trial

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Treatment with sulfonamide precipitated psychosis and pronounced hemolytic anemia in one of these siblings

Serum analysis of 32 patients with high-frequency migraine revealed abnormally low levels of alpha-lipoic acid (ALA) and lactate, along with abnormally high levels of peroxides in 46.9% of the patients, further supporting the role of oxidative stress and metabolic alterations in the pathophysiology of migraine (40)

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