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These results suggest a potential regulatory relationship between thymosin beta 4, microRNA 146a expression, and downstream inflammatory pathway modulation

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In SURMOUNT-1, 72 weeks of tirzepatide induced mean WL of 1622.5% in people without diabetes compared to 2.4% with placebo, with no sign of the weight plateauing, suggesting that there may be further WL with long-term use [46]