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The temporal profiling revealed critical insights into the developmental trajectory of hepatocyte and cholangiocyte differentiation, in addition to identifying increased cellular heterogeneity by Day 45

doi: 10.1096/fj.202001763RR 85 RamsayGCantrellD

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Firstly, it needs to be reduced to Fe 2+ by gastric acid or the action of cytochrome b heme reductase 1 (duodenal cytochrome b, DCYTB), before it can be transported into the small intestinal villus cells by divalent cation transporter 1 (DMT1)