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Dietary vitamin A or retinol is converted to retinaldehyde by ubiquitous alcohol dehydrogenases and then irreversibly acted on by cell-specific retinaldehyde dehydrogenases to generate its active metabolite, retinoic acid (RA), which binds to the RAR and RXR nuclear receptor families and function as transcription factors (11)

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So far, Retatrutides safety profile looks similar to Ozempic mostly mild, GI-related side effects that tend to improve over time

[1] By increasing GH secretion, sermorelin can raise insulin-like growth factor 1 (IGF-1) levels in the body