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The size of the molecules selected may permit understanding of the different routes of transport, with molecules such as inulin, polyethylene glycols (PEGs) and Fluorescein Isothiocyanate-Dextran (FITC-Dextran) being utilised for assessment of the paracellular route, whilst larger molecules such as horseradish peroxidase can be utilised for assessment of the transcellular route [21]

These unstable molecules can damage cellular structures, including those of immune cells

Diabetes Vasc Dis Res (2011) 8(2):11724

Study of Danielsen and coauthors was one of the first findings demonstrating the role of PLCE1 as tumor suppressor