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Unprecedented Weight Loss In clinical trials, participants on Retatrutide lost up to 24% of their body weight over 48 weeks

Safe, sustainable reduction often occurs over 612 months depending on starting weight and consistency

This synergy also induces neuronal death: microglial ROS (O 2 - ) and cytokines directly damage neuronal mitochondria, while astrocyte-mediated glutamate excitotoxicity (via calcium overload) and reduced neurotrophic factor (e.g., BDNF) secretion jointly promote apoptosis, necroptosis, and ferroptosis [268,269]

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Goh said will worsen over time without treatment