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By modulating the host immune response, HDT ameliorates immunopathological damage and improves overall outcomes by promoting autophagy, antimicrobial peptide production, and other mechanisms

A Phase 2 trial found IGF-1 levels plateaued at month 6 despite continued daily dosing, suggesting partial desensitization of the GH-IGF-1 axis under constant stimulation

Dec 2018;18(6):333-337

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