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Among the integrin analyzed, laminin-binding integrins require a proper PM lipid raft assembly to recruit the transduction machinery and activate the downstream pathways 54

These alterations contribute to systemic inflammation by increasing the production of pro-inflammatory cytokines, including interleukin (IL)-1, IL-6, IL-8, IL-13, tumor necrosis factor-alpha (TNF-), and transforming growth factor-beta 1 (TGF-1) [24]

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423,424 In addition, insulin and IGF1 inhibit sex-hormone binding globulin (SHBG) synthesis, although both hormones stimulate ovarian synthesis of sex steroids that can promote cellular proliferation and inhibit apoptosis in breast epithelium and endometrium