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While tirzepatide already exists as an incretin-based drug with superior weight loss outcomes, an oral formulation like orfoglipron could may increase treatment acceptability and adherence

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BYDUREON versus Sitagliptin and Pioglitazone, All as Add-on to Metformin Therapy A 26-week double-blind comparator-controlled trial was conducted to compare the safety and efficacy of BYDUREON to sitagliptin and pioglitazone in patients with type 2 diabetes whose glycemic control was inadequate with metformin therapy (Trial 4 - NCT00637273)

GLP-1 analogues did not increase the risk for pancreatic cancer when compared to other treatments (OR 1.06

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