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10.1515/mr-2023-0028 [DOI] [PMC free article] [PubMed] [Google Scholar] Wei L., Lin Q., Lu Y., Li G., Huang L., Fu Z., et al

The schistosomicidal activities of PZQ and of potassium antimonial tartrate, a drug used in the past for schistosomiasis and a TGR inhibitor, are reduced in immunosuppressed mice 65 , indicating a crucial role of the host immune system in the mechanism of action of schistosomicidal agents in vivo

Studies suggest that erastin and its analogs antagonize the functions of free tubulin on voltage-dependent anion channel 2/3 (VDACs) and induce the opening of VDACs

We propose that integrating in vivo biological constraints and microenvironmental complexity is essential for the rational design and successful translation of ferroptosis-targeted therapies