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Signaling and Synthesis: The prolonged, unbound presence of IGF-1 LR3 in the bloodstream maximizes the anabolic signaling effect on muscle tissue, activating intracellular signaling pathways that promote protein synthesis and muscle fiber hypertrophy (increase in cell size)

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In populations who cannot exercise due to frailty, physical disability, or cardiovascular limitations, MOTS-c represents one of the most compelling candidates in the emerging class of pharmacological exercise mimetics