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Further, chronic alcohol intake can lead to severe niacin deficiency through reducing dietary niacin intake and interfering with the tryptophan-to-NAD conversion (30)

Given that apoptosis and autophagy are mutually inhibited, apoptosis facilitates Gal-9-mediated autophagy reduction, which results in the decrease of invasiveness in the trophoblastic cells, and the obstruction of spiral artery recasting, hence placental hypoperfusion (96)

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Across both trials, the reported safety profile was described as consistent with prior experience for the compound class, with gastrointestinal adverse events predominating

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