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A reduction in Na + /K + -ATPase activity directly results in membrane depolarization, which not only impairs the efficiency of action potential generation and propagationpotentially constituting a direct electrophysiological factor for myasthenia at restbut also brings the membrane potential closer to threshold, thereby inducing muscle hyperexcitability (manifested as fasciculations and painful spasms)

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There is not enough highquality safety data in pregnancy or breastfeeding