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The integrated area under the curve (iAUC) was calculated using the glycemia measure immediately before PBS/GIPR antagonist administration

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The researchers found that CJC-1295 was safe and relatively well tolerated when administered at doses of 30 or 60 g/kg, without any notable adverse effects observed

Increased levels of redox metals act catalytically and contribute to the formation of damaging ROS and the occurrence of oxidative stress in the brain via the Fenton reaction (Valko et al