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The most frequently reported symptoms include nausea, vomiting, decreased appetite, and mild abdominal discomfort

Spatial transcriptomics combined with single-cell RNA sequencing identified high expression levels of ferroptosis-related genes, including TFRC, NCO4, and SLC3A2, in granulosa cells of patients with ovarian senescence, while GPX4 expression was notably low ( BNC1 mutations that lead to premature follicular activation and atresia (Zhang et al., 2018)

doi: 10.1172/JCI98747

Similarly, GIPR rs1800437 influences glucose-dependent insulinotropic polypeptide (GIP) receptor function, which becomes relevant when considering dual GLP-1/GIP agonists like tirzepatide

Protein lysates from cellular or tissue samples were prepared using cold RIPA lysis buffer