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While the FDA does not specify a required washout period before conception, tirzepatide has a half-life of approximately 5 days, and some clinicians may recommend discontinuation several weeks before attempting conception based on pharmacokinetic properties

Nat Commun 12(1):330 Theodorakis N, Kreouzi M, Pappas A, Nikolaou M (2024) Beyond calories: individual metabolic and hormonal adaptations driving variability in weight Management-A State-of-the-Art narrative review

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Proglucagons enzymatic cleavage varies depending on the tissue and is modulated by specific prohormone convertase enzymes

The Nrf2/Keap1 system is responsive to many challenges, particularly to oxidants and electrophiles