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After diagnostic excision, the next step is wide local excision of the wound with a 1020 mm margin of normal tissue

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The study found that pre-operative fasting for 3 days reduced infarct volume in rats with severe focal stroke, and the neuroprotection was associated with the regulation of innate immunity: elevated circulating neutrophil chemokine ligand 1 before ischemia and reduced pro-inflammatory markers (TNF- and its receptor, as well as downstream intercellular adhesion molecule-1) in the striatum after reperfusion

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