Similarly, endpoint brown adipose tissue and liver weights were significantly reduced with RETA, however there were no differences in spleen weight (Supplementary Fig
In addition to locally produced GLP-1 (116), GLP-1 crosses the blood-brain barrier to agonise GLP-1R within hypothalamic CNS centres, where ingestive behaviour and satiety is dictated [(117)
Other than side effects, the high cost of the drugs is also a leading cause of discontinuation, according to a separate study by the American Diabetes Association
Furthermore, even after the initiation of insulin therapy, uncertainty remains regarding which additional antihyperglycaemic agents should be introduced and at what stage, especially in the context of long-term GCs treatment
This is suggestive that the snack products carbohydrate digestion may be delayed, conferring a positive effect on glucose absorption