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There are several mechanisms proposed in attempt to explain copper irritancy

Rachid R, Umetsu DT (2012) Immunological mechanisms for desensitization and tolerance in food allergy

insufficient sleep increases cortisol levels and insulin dysregulation, while mild dehydration reduces plasma volume, which may affect exercise performance and favor fat retention

Role of islet GLP-1 in alpha-cell heterogeneity Evidence that the alpha-cell proglucagon processing profile is dependent on the differential expression of PC1/3 versus PC2 suggests that alpha-cell GLP-1 production may function as a marker of alpha-cell heterogeneity