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Mitochondrial Biogenesis and Thermogenesis: Investigating how the glucagon receptor activation arm alters oxygen consumption and energy expenditure at the cellular level, particularly within brown adipose tissue models

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Mechanistically, they activate Nrf2 and block ubiquitin-mediated GPX4 degradation, thereby inhibiting ferroptosis and alleviating cartilage erosion, pain, and gait abnormalities in DMM-induced OA (192)