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The general notion that the testicular damage precipitated by temporary ischaemia is associated with oxidative stress is supported by the sudden induction of lipid peroxidation and the concomitant suppression of endogenous antioxidant activities including SOD, catalase and glutathione peroxidase.17,5557 In addition, the tissue injury induced by testicular torsion/detorsion can be dramatically alleviated by pretreatment with exogenous antioxidants such as selenium, resveratrol, L-carnitine, caffeic acid phenethyl ester and garlic extract.17,5760 Finally the enzyme purportedly associated with reperfusion injury, xanthine oxidase, can be inhibited by allopurinol and the latter is known to reduce the testicular damage associated with testicular torsion.56 Notwithstanding the importance of xanthine oxidase-mediated oxidative stress it should also be noted that neutrophil infiltration into the testes following torsion may represent yet another source of uncontrolled free radical generation responsible for mediating the pathophysiological consequences of temporary testicular ischaemia.61 One of the major issues associated with the clinical management of unilateral testicular torsion is whether the ipsilateral testis should be removed in order to preserve the contralateral testis
