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Drugs in development: Retatrutide is a triple agonist that targets GLP-1, GIP, and glucagon receptors

For semaglutide specifically, the SmPC advises discontinuation at least 2 months before a planned pregnancy due to its long half-life

More help Considerations for Potential Applications of the AOP (optional) Addressess potential applications of an AOP to support regulatory decision-making.This may include, for example, possible utility for test guideline development or refinement, development of integrated testing and assessment approaches, development of (Q)SARs / or chemical profilers to facilitate the grouping of chemicals for subsequent read-across, screening level hazard assessments or even risk assessment

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