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Succinate Modulation of Immune Functions As discussed in detail in the Metabolic Alterations Associated with Cancer page, and briefly above, increased levels of succinate in the cytosol result in the inhibition of the PHD enzymes that hydroxylate, and thereby destabilize, the HIF-1 subunit of the HIF-1 transcription factor complex

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Yet, the most effective way to boost glutathione levels is to take glutathione itself

The transcription levels of antioxidant enzyme genes such as CAT, cAPX (cytoplasm ascorbate peroxidase) , G-POD, Cu / Zn-SOD and GR were significantly increased under the HT treatment relative to the NT treatment (Fig